Too much methylfolate reddit. Long story short, too much folate is not good for us.

Too much methylfolate reddit I just saw that too much of it in one’s system could cause increased anxiety. Now Im trying to increase the dosage slowly and have been having good results. But actually, slightly too much folate, but not a lot, can also make me feel odd too without drifting me into sleep. This has happened to me. The dose of methylfolate is selected individually by gradually increasing the dosage, no one knows how much you personally may need. So you might feel a little worse before it gets better if (which is why too much folic acid can raise cancer risk, but even 10-100x as much methylfolate doesn't) As for your last line, I'd say both. I didnt exceed 400mg dosage and day by day symptoms got worse till worst mast cell flare up showed up. You will likely be low in potassium making you feel on edge. I have an appointment with an Integrative Medicine specialist in May, but it would be nice to find a supplement before then! Just from the 200 micrograms in a multivitamin. E. If not, I can take up to 15mg as well. L-methylfolate too much . ” A nontrivial percentage of the population cannot convert adequate amounts of folate, an important B vitamin, to methylfolate, often due Yes, it is possible. I stopped taking the methylfolate on Tuesday when I realised, but not much improvement yet. I feel lucky I actually know about these effects of methylfolate. So, I take the one a day advanced prenatal which has folic acid, and on the off chance my body isn’t processing it, I’d like to take a straight methylfolate supplement. I began with 1mg, then 2mg the following day which was too much for me. TW: Miscarriage I am jumping on this thread because I’m also heterozygous for A1298C and learned this less than a month ago. Turns out having too low homocysteine levels is a thing and can host a host of problems. Then yesterday I heard a JRE podcast about how the US sprays everything with Folic Acid unless it's organic and supposedly 40+% of people can't process it and it's poisoning them. My doctor asked me to stop the supplement asap. Prior to this, I had been taking escitalopram 10 mg for depression for 2 years. I see that you can take too much folic acid but not sure if taking methylfolate on top of folic acid would put me over a safe limit Posted by u/chinawillgrowlarger - 15 votes and 26 comments Choline would support the alternate remethylation pathway, so it shouldn't be too much because the remethylation would just get partitioned more favorably to this alternate pathway. That reaction turns the homocysteine into methionine. Sometimes it feels like I'm taking too much- I can't explain why, it's just an off feeling. too much Methylfolate cured my depression and is helping me handle chronic fatigue, but Im still figuring out the dosage. I felt great the first week but after that I've been in the worst depression ever. I My psychiatrist prescribed me L-methylfolate to help my anti depression meds do their job. ) Heard about methyl folate and decided to try it out since it wasn’t too expensive online (Now brand, Amazon). Sam-e is the main methyl donor in the body. Reddit: a social network where you can find people who agrees with you and your theories Methylfolate, at lower doses, is the better supplement to take. Eat healthy and take probiotics. Long story short, too much folate is not good for us. I'm a 42 yo man living in Russia. 500mcg is still too much for im no expert at it by any means, but i use methylfolate and methylcobalamin from time to time with good results reduces autistic traits and takes away depression for me. If you have too much serotonin reuptake happening, serontonin levels will be low. My doctor is great but I'm not sure she knows a Ken, it’s because neurotransmitters require folate to function. My symptoms are too extreme and too long lasting to be caused by some vitamins. The past two mornings I've taken methylated B12 and P5P (B6). If you have lived your life with methylation issues then start supplementing Methylfolate it can have a honeymoon stage then cause some side effects for long while before resolving and I believe potassium is particularly important. I'm on a pretty high dose (15) of l-methylfolate. Most methylfolate supplements are in that range. g. Then you would have produced melatonin during the day, when it's usually produced much more at night Get the Reddit app Scan this QR code to download the app now. So I take a supplement version of the 15mg l-methylfolate (it's much cheaper if you can't get Deplin covered by insurance) and 5000mcg of methyl-b12. After 3 weeks I suddenly fell into severe deficiency symptoms (weakness, brain fog, fatigue, blurred vision but no bloating. If you have an abundance of methyl it will create irritability. Hey guys, So I took 400mcg of Methylfolate and been experiencing some intense anxiety now a few hours after. Early Feb I switched to methylfolate 1mg daily 11th March switched to 5mg methylfolate daily. hey, i’m going through the exact same thing, severe anxiety all day. At first I didn't feel any changes, so I kept taking it. Recently learned I have a mutated MTHFR gene and for starters WOW. Do NOT rely on a Serum Folate to tell you what's going on. In addition, you have homocysteine in your Hi there. Also my homocysteine was BELOW the recommended level somewhere in the 4, forgot the measurement unit. Too much C, too much fish oil, high doses of many B vitamins can also increase acetylcholine synthesis. Even 100 mcg is too much! Yeah, I could take only methylfolate, but my research indicates it needs to be balanced with other B vitamins. I started taking 5000mcg methylcobalamin, 800 mcg methylfolate. Help me make sense of folate . But it depends on every person I guess. Hey there, I got benefit when I supplemented with it alone . I got genetic testing done, found out I have a folate deficiency and an inability to process folic acid, began supplementing with methyl folate, and my symptoms are like 80% better on a daily basis and my only side effect is a little acne on my back when I take too much folate L-5-MTHF (L-methylfolate) B12 (cobalamin) Methionine Homocysteine Folic acid Here is the goal: We want healthy serum levels of L-methylfolate, B12 and methionine (not too much, not too little) We want as little serum homocysteine as possible (it NAC used to clear my fog, but now methylfolate seems to do the same and make NAC do pretty much nothing, so I suspect I really do have low methylation capacity at least as one of my problems, since low methylation would also probably Ever since initiating the methylfolate, I've had a major, life changing difference with my mental health and just how I think, regulate mood, my self talk, etc. But methylfolate is better absorbed, people with common MTHFR mutations can't utilize folic acid well, and the more folic acid they have, the worse issues it can Too much folate can be just as harmful as not enough, so I encourage you to have your blood taken to check. If methylfolate is in any way better for you, you have methylation issues, and taking methylfolate is just a tiny part of what you should be doing. General Discussion I (M38) started supplementing Methylcobalamin 1000mcg and methyl folate 1000mcg daily due to B12 deficiency, right after I started I noticed that I urinated too much not like normal, and the amount of urine also is much higher than normal. It sounds like POTS, SAMe is used with COMT to break down neurotransmitters which can screw with your blood pressure and mood specially Get the Reddit app Scan this QR code to download the app now. I am homozygous C677T. I have tons more energy and focus, and feel much better overall. The symptoms for me have some very clear changes from the B12 deficiency/supplementation waves. Thank you for your answer mate. I do Thorne prenatal (methylfolate) and my specialist has me on metanx. If you’re on Facebook there’s a helpful group called mthfr ttc and pregnancy pregnancy loss (I think or something This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. Or check it out in the app stores   That's way too much. I, personally think it should be recommended for every woman. I wouldn't trust the test so much, they are too unspecific. Taking too much methylfolate can cause side effects, such as severe anxiety, nausea, insomnia, migraines, irritability, achy joints, headaches, and more. I personally just take complex B with just 200µg a day and I'm Homozygous C667T. It just felt real nice” [4] Hello everyone, I'm seeking advice because I'm not sure where to turn with this, but I've been supplementing for 2 weeks with 400mcg of methylfolate and 50 mcg vitamin B12 (cyanocobalamine) since my folate levels were low at 5. Maybe I missed that section but what I got from that article is that just consuming folic acid causes a state where the mice have reduced methylation capacity and reduce methylTHF. It's nearly impossible to overdose as it is water soluble. I've seen on this site that some doctors are prescribing niacin to This can cause “methyl trapping”, where the excess methylfolate is unable to be utilised in the methionine cycle (through the MTR enzyme) as usable B12 levels are too low. Iron utilization. I wouldn't put too much stock into poorly/un defined medical terms like under- and over-methylation. Folate bad for undermethylating depressives Me too. just curious which fat oxidation disorder you have and how did you figure it The correct approach and the "solid science" approach is to try and establish how to clearly and properly test if methylfolate would be appropriate or not. So I was on 5mg daily for 1 month & have not been taking any for a week. I can't imagine how many people start a multivitamin with methylfolate in it and after a while develop mental health issues because of it, but aren't able to understand that methylfolate is causing this and they just keep taking it. Different solutions (holistically) recommended for different people. I also taking 2000 methylfolate I don't think we actually need 15mg. I read somewhere, methyl-vitamin Bs make Mcas worse! I myself have MTHfR gene mutation too, i took methylfolate 400mcg. It requires a prescription and has to be delivered through the mail, but it often costs half as much as generic methylfolate from a local pharmacy. Just one methylfolate pill is enough to send me down the depression black hole for the next ten or so days. I just now realized each tablet contains 5,000 mcg of methyl B12 some 200,000% of the RDA. But I’m guessing too much of it without enough amounts of tryptophan or other serotonin precursors may keep the levels in your brain or body down. Or check it out in the app stores My provider started me out with a 15 mg dose and it was way too much. Not to mention how often even people who need it expereience issues with too much methylfolate. If I take too much methylb12 and start going into overdrive, I need methylfolate to stop it, then niacina and glycine work much better to reduce methyl groups and calm me down. With that plus 400mcg/day after that period, I had slightly too much 5 months later. If I just recently was prescribed folic acid (though I requested methylfolate bc MTHFR) and quickly realized it triggers migraines for me. Two or three times a week. Lowering the dose as low as 25mcg for methylfolate is sometimes needed to curb the side effects, and you can slowly add 25mcg a day from Yes I've been taking methylfolate since this post, I am homozygous for mutation 667. After supplements Methylcobalamin and Methylfolate I started to urinate too much. 400 mcg methylfolate 500 mcg methylcobalamin I used to take 1,600 mcg methylfolate but found 400 mcg is just as effective. but later when i added methylcobablim it was beneficial too. There is also research on ketamine but that would be very dangerous to attempt on your own. Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Careers Press. Methylfolate is only used in one enzymatic reaction, in combination with B12 and homocysteine. Any concerns for taking this much B12 daily? I would like to take 2 tablets per day after starting to get more folate, but that seems like a super high Get the Reddit app Scan this QR code to download the app now. That seemed too much. I had one too and it was devastating. Reply reply Get the Reddit app Scan this QR code to download the app now. So if B12 is very low, too much folate is trapped in the methylfolate form, waiting for a turn. (Since it made no difference in that regard, even after four months). AIP tends toward deficiency in calcium, magnesium, manganese, molybdenum, lithium, and silicon. If u have high homocystein level, vitamin C also good for homocysteine. Or check it out in the app stores   I’m taking methylfolate (for a few weeks now, started at 1mg, currently at 3mg) but it seems to be making me anxious. Some of your genes are turned up too much in the methylation cycle and others are turned down. my joints get a little bit sketchy if i take too much methylfolate though. Most people already get waaaay too much folic acid in their diet. i see lots of people say they are sensitive to methylfolate and replace it with folinic acid, but methylcobalamin doesn't seem to be mentioned as much in such contexts. Is it too much? Fuckin probably. Here is the link, and there is a comment mentioning the histamine intolerance. So many people have the mthfr mutation, but other factors can reduce our natural ability to convert folic acid to l-methylfolate. Or check it out in the app stores Can I go from undermethylation to overmethylation with too much methylb12 and methylfolate? Question I learned about methylation a few years back, took the 23andme test like many of you, discussed the results with my doctor, and began I am getting much better and controllable improvements if I focus on downstream systems that rely on folate like the choline and creatine synthesis ones. Too much methylfolate causes depression, and the addition of B2 only helps curb irritability. So 400mcg is great for 2 days then becomes too much. Methylfolate vs Folinic Acid . After about 4 weeks of riboflavin 3x daily, my MAO A enzyme started working properly THEN I could go back and take B-complexes containing methylfolate like B-right and not be overstimulated. If that's the one thing you're missing, yeah, it might make you feel better. If you've not already run across the advice to eliminate folic acid from your diet, that may make a significant difference too. Your body only methylates a certain amount of folate but by taking a massive dose of methylfolate you’re bypassing your body’s ability to regulate methylation. Here's the thing: the two mutations commonly tested for are only 2 of something like 40 genes suspected to be involved in methylation so they're a horrifically incomplete picture of what may be going on. The study of Methylation and it's effects on the brain is still incomplete, particularlly when it comes to treatment. In my case, many supplements were "too much" and created anxiety and uncomfortable feelings. Mild deficiency is almost unnoticeable, but as soon as you do something that puts extra load on those vitamins, you'll notice it. I now alternate days, and or reduce dose to . I have other confounding factors like dysfunctional childhood and cocaine addiction but I believe MTHFR is the primary reason I had ADHD. A significant proportion of the population (at least 20% of all people) have a very common genetic variation (MTHFR) that makes them unable to absorb folic acid; worse yet, it can block their absorption of actual folate present in the foods that they eat, which can contribute to fatigue Deplin brand methylfolate (7 mg or 15 mg). Or check it out in the app stores   SLC19A1 and MTHFD1 SNPs in methylfolate production Or else you'd be relying on Choline pathway too much and that surely has a detrimental effect? I noticed a massive change from Choline (similar genetic markers to the OP), but boosting Folic acid undergoes a very slow conversion to folate via enzymes, and having too much folic acid in your body isn't exactly a good thing. I can only Interesting. You could be low, get a lot of iron, and your body will be upset from too much incoming iron and it not being able to properly move it, with things like hepcidin In clinical trials of Deplin, which is prescription methylfolate, there were no significant side effects recorded. One mistake I made with AIP was not getting enough calcium and magnesium which caused poor sleep. You could try 1000mcg but I suspect it won't provide any added benefit. In my opinion, Any amount of folic acid is way too much if you have access to L-5-Methyltetrahydrofolate especially if you have a MTHFR mutation. I’ve been taking l-methylfolate for about 3 years at 15mg because I was told I have the MTHFR gene. but i need it regardless of anxiety otherwise fatigue digestive issues allergies and brain fog eat me alive. The HNMT enzyme is what makes histamine dependent on methylation because it uses s-adenosyl methionine (Sam-e) as its cofactor. Methylfolate - Please Share Your Experience With It . Before Methylfolate, i was coping with my symptoms using supplements and diet, including 10 eggs a day, creatine, non methylated b complex, and much more, everything was absolutely perfect UNTIL The day i tried methylfolate, One SINGLE dose of I'd lose the mixed one and just take the individual methylfolate and B12 so you can dial it in. I lowered the dose to just the Biovite (250mcg methylcobalamin and 400mcg of methylfolate). Chris Masterjohn recommends choline as an alternative methyl donor for that Never worry about too much b12. Tons of vegetarian stuff is supplemented with folic acid. 2. I had pretty bad effects with 800mcg methylfolate. 15 minutes later and when I did it again I got a light feeling of pins and needles (which I just noticed doesn't happen almost ever nowadays). No other Rx drugs other than blood pressure. I didn't want to take the prescription folic acid (5 grams) because it felt like too much, so I took 800 mcg for 2-3 months. I had read about L-methylfolate being helpful in some cases of depression as an add-on to antidepressants, so I tried just that. HNMT enzyme adds methyl group to histamine using Sam-e. Way too much energy, and I can't fully calm down, yet it's very easy for me to focus without trying. Whenever people doubt the validity of methylfolate I like to point out that you can get it prescribed under the Get the Reddit app Scan this QR code to download the app now. Meanwhile, some people start right at 15mg, and barely have any side effects at all. P-5-P would be worth adding in as a cofactor too. Vitamins A and K seem to lower acetylcholine. 4mg a day and you are taking 2mg a day of an active form it is way too much. Choline would reduce need for B12 and methylfolate somewhat, so over time you could reduce those in dose or frequency (e. Be careful of too much folinic acid. to be the sweet spot for me, occasionally I have an extra 200 if my mood drops, but I have to be careful There are some people that say even taking too much Methylfolate/Folate in general and even just B12 can cause some issues involving Methylation, don't know too much about that but would make sense, you wouldn't find such high doses of these nutrients in nature anyway Reddit . A few days afterwards, I reduced my Methylfolate to 400mcg, and that has been working much better - still having the mental clarity/lucidity without the brain fog. If I stop for a week then come back, I again get 2 great days, so that means I'm probably overmethylated after 3 days of 400mcg. 2nd question is how does overmethylation cause anger, irritability, and sometimes intense internal rage? I notice myself sometimes over reacting when over methylated. Or check it out in the app stores It’s as if the body must utilize all of it at once because it is in active form pushing the body to try to do too much at once. If not eaten from natural sources, the methyl folate can be taken to supplement the slower reactions. I'm heterozygous for 677t and started taking methylfolate 2 months ago. I heard it's wise to use them at least a little before you start on methylfolate. My BP seems to be unaffected by this new supplement (consistently 117/77) so I’m keen to keep taking them. I took a prescribed b complex vitamin in addition to my prenatal while I was pregnant and had debilitating migraines 4x as 1000 µg a day is too much specially that potent form of folate. e. Or check it out in the app stores   Methylfolate is all over the place can only tolerate very low doses. My anxiety has spiked over the last couple months for some reason. A back-up of NAS could have been taken care of by increased SAM that was produced by the methylfolate. I was recommended to start taking 15mg of l-methylfolate a day. And often people with MTHFR are low on other cofactors too. 5mg depending on if I'm eating foods that contain methylfolate that day. Get the Reddit app Scan this QR code to download the app now but I've been wondering how much is too much? I already take methylfolate, methylB12, & Quercitin. If you have too little, serotonin will be too high. And again, the L-methylfolate was given along with an SSRI/SNRI. Methylfolate is also required for serotonin production somehow. I do not know of a specialist personally so can't help on with that. You're psyching yourself up. Tried doing Methylfolate 400mcg even though I’m slow COMT and after 4 days or so my arms feels like they are vibrating or have a very mild burn Coins 0 coins View community ranking In the Top 1% of largest communities on Reddit. In medical literature, however, demyelination and other B12 deficiency symptoms have been recorded as people with borderline B12 status who corrected their folate deficiencies found that their low B12 stores were rapidly used. Or check it out in the app stores     TOPICS. Not totally sure the implications of this for my supplement regimen. Then I started working with a dietician and radically changed my diet. However, I still feel some of the side effects of the 800mcg at a lower intensity (like dizziness, minor akathisia), so I think I will even try decreasing to 200mcg for a while. can it also induce overmethylation? should one avoid taking both at the same time, or avoid taking too much methylcobalamin? I'm surprised then you don't mention a methyl B12, given mega dose would exacerbate such issues too. Too much B6 is bad especially - I wouldn't supplement any if I were you. He's now running more tests. View community ranking In the Top 10% of largest communities on Reddit. I ordered a Jarrow version of methylfolate, (800mcg) that has B6 and B12 in addition to the folate. If you added-on more in supplement form, then added 5-MTHF in addition I would expect that to have a negative effect. For example I was prescribed 4mg/day for 40 days when I had a similar deficiency. I was taking Jarrow's b-right and a methylated multi called BioVite. I was actually diagnosed with Graves’ disease while supplementing methylfolate and I kind of believe it precipitated my diagnosis. Do you have MTHFR? 10mg is ridiculously high to start off with, especially without b12. I suspect it’s an autoimmune disorder. Folinic acid is active, just like methylfolate, but doesn't seem to have the strong negative side-effects that methylfolate might have. I have a hard time tolerating methylfolate. I actually find Folin-ic acid to be much more stable than methyfolate. “It’s just a supplement, surely it won’t have any side effects/etc” WRONG lol Bought 6 bags of oat cereal (Purely Elizabeth, Organic Ancient Grain Granola) and I've felt fine after consuming way too much. Too much choline or acetylcholine, foods that contribute to it. If there is too much histamine in the body, too much Sam-e will be used and the methyl groups will be depleted. You’d only need that much if you have two copies of an MTHFR gene that impairs the methylation of folate. (Of course, you could also eat more vegetables) IME, I can only take very small amounts of B2 (around 2mg) or it makes me lethargic/depressed, likely due to B2 breaking down MAO enzymes. Snake oil is still sold but under different names now. It sounds like your doctor suspects you have a MTHFR polymorphism. I've registered on Reddit to post an answer. 5 mg is a lot for the average person, although for some types of depression that are Whenever I take higher doses of methylfolate/B12 I feel overmethylated and either feel down or anxious, but TMG and NAC do not seem to have the same effect (at least not as much). So simply eating a ton of folate isn't necessarily going to help you too much and definitely won't solve the full scope of the problem. It’s very possible. You mention being vegetarian. This is why there has been no upper limit set for b12. I'm a 27-year-old girl, earlier this year I did a blood test and saw I have relatively low folic acid - 3. After waiting a few days and not noticing anything I tried 15mg a few days too, but no noticeable difference. The same same symptoms that methylfolate supplementation typically helps with, can trigger those Methylfolate supplements can come with side effects, even if you “have MTHFR. 3 ng/ml. Or check it out in the app stores   Because too much is overmethylation But this words is that I have a Methylfolate Score with a 42% decrease and says to eat seven eggs. reReddit: Top posts of June 13, 2022. methylfolate) & can lead to poor concentration, anxiety, panic attacks, & sensitivities to environmental toxins, among other symptoms. ) It’s best to get in diet only but you can check levels Those who have MTHFR mutations (especially the C677T MTHFR mutation) learn that methylfolate is critical to take – and that folic acid is critical to avoid. TMG, for me, is easier to dose and includes glycine, which is a plus, and once it loses two methyl groups becomes sarcosine (I believe). too, folic acid, folinic acid, methylfolate. I take methylfolate in addition to my Thorne basic Prenatal which also has (a smaller amount of) methylfolate in it. When you’re eating poorly and under stress, your gut has more gram negative bacteria, like e. It can lead to conditions that include ADHD, binge eating, addiction and Yet as far as focusing on tasks or bettering myself has been, not much has changed. This makes SO MUCH SENSE. And I would take a high dose of a good b complex with 100 mg of all the b vitamins (except b6 and folate), at least 400 mcg methylfolate (add more methylfolate if needed) and 10-25 mg P5P. I was prescribed 15mg for depression, but it makes me very very anxious and I don't want to use methylfolate as a treatment for depression necessarily, just for the MTHFR illness. coli, and if you don’t decrease their populationwell, they like l-methylfolate too. Or check it out in the app stores   My dr prescribed 15mg of methylfolate for depression, but I'm wondering if it's too much? (The dr has not seen these results). My mental health has been in a terrible state for a while, maybe longer than i’ve been on Too much puts you into overmethylation. I have followed Dr. Folate or folic acid appears to turn this gene on. 4 nmol/L and I read through parts of that first article and nowhere did it discuss that folic acid blocks the ability to absorb methylated folate. He had me on 15mg a day and my anxiety increased 5 fold and I started having severe panic attacks thinking it was my Delta-8 THC. My Folic Acid levels were in the 15ug/L+ range. I was thinking I should catch up on lost B9. 5 hours. Yup, I was. Then that got to be too much so I started taking it only when I started losing motivation. (Yes, you can have too much serotonin in your body and some people do. So sorry for your previous loss. What is L-Methylfolate (5-MTHF)? Why methylfolate and not folate? I now think something else is responsible for my condition. Folinic Acid plus the riboflavin feels good now. All the oldschool research was done with folic acid, so the claims are for folic acid. And the whole energy metabolism and krebs cycle is so complex, u can't just optimize everyone who has an MTHFR SNP with B9. My serum folate is 5. Also at least 300-600 mg magnesium which is needed to absorb the b vitamins in such high doses, a deficiency also leads to massive anxiety, fatigue, muscle pain. One week was fine, then symptoms of methylfolate side effects occurred. Could it be too much dopamine lowering serotonin? Maybe just too much dopamine? Or maybe am i missing a certain nutrient, ie low homocysteine causing a methyl block? Idk It's almost like someone else wrote this particular article. I realised on April 11th so stopped taking methylfolate. I switched to methylfolate, which felt gentler to me (folinic acid and adenosyl hydroxo B12 felt like I was on too much). If you do take 5mg/day, don't take that for too long. 5 microg/L on a lab normal range of 3-20 so I think that's low especially since I've just discovered I can't turn much of it into methylfolate! B12 was 541 ng/L on a normal lab range of 180-900 so not too bad. I am now 7. Using methylfolate if you are overmethylated (produce too much SAM-e) and thus too much serotonin will have a I started out taking 1000 mcg/10 mg daily. or any folate other than in meals. My doctor recommended extra folate and a gluten free diet to avoid “enriched” foods that have folic acid added. The methyl/folate ratio has a powerful impact on gene expression of reuptake transport proteins (page 13). Methylfolate creates a weird agitation in me after a certain dose. About four months in it became too much and I went down to 500mcg/5mcg daily. (and turns off other methyltransferases). im gonna try 50 mg nicotinic acid as a fix because im sensitive to methyl donnors cause of ComT, so that might be the issue. Not sure if methylfolate is the culprit, I guess I'm going to stop it for a week and see what happens after reading this post. Remember, too, that just because you have a mutation doesn't mean it's active. How do you determine which to take, especially if you have an MTHFR gene mutation? I switched to Folinic Acid at first when methyl folate was too much at the start, and it had similar but milder onset symptoms. Methyl-B12 + Methylfolate (Jarrow Formulas, 1/4th of a tablet) B-Complex 1x/week 10mg P5P 15mg Zinc Vitamin D3 5000IU 250mg DMAE View community ranking In the Top 10% of largest communities on Reddit. I’ll try not to get into a big rant here on that and get to the point. Even 100mcg is sufficient. I've been feeling a lot better than when I was doing basically the opposite of higher methylfolate and much lower riboflavin. I was able to increase my B12 to 100mcg. Also taking magnesium chelate with the B6 and B12. It's definitely a thing & I'm pretty worried it's caused me a lot of problemsMethylfolate Side effects There is a correlation between ADHD and MTHFR mutations, but you need a genetic screen to confirm this (blood work may show elevated levels of homocystine, but not 100% conclusive - testing for folate is a bad indicator, as folate will still be present in blood regardless) not everyone has the mutation and consuming too much L-Methylfolate can It seems it could, as well with serotonin and norepinephrine as SAM-e is required for the synthesis of all of those, and that would get used up pretty quickly for the synthesis of methylfolate or methyl b12. Heart beating, tightness of chest etc. Still couldn't increase my B12 dose, so I figured I was still high. For example if you take folic acid, it needs to be converted by the DHFR enzyme which is slow in humans, it can only convert like 200µg a day when the RDA is 400µg. Your body needs to recalibrate this complex network of chemical interactions to changing methylation, so starting with low doses and working up incrementally over time can prevent/minimize those side effects. The body prioritizes them in different manners and sometimes will methyl the vitamins (if unmethylated) for other functions. Or check it out in the app stores   RDA of folate is just 0. My mthfr specialist doc has me taking 200 mg riboflavin, and only 230 McG folinic acid. L-methylfolate allows us to synthesize neurotransmitters. I've also been prone, my entire life, to anxiety and depression (also have ADHD and take Ritalin [Methylphenidate for it) - started taking Escitalopram (Cipralex/Lexapro) but didn't notice much benefit from it even after 3 months. Reduced it to 400mcg and felt much better after a couple of days. But a lot of people start taking methylfolate only to run out of some other cofactor, like other B vitamins, magnesium, zinc, etc. However, too much mehylfolate will actually shut the methylation process off and lead to fatigue, muscle or joint aches, depression, etc. Google the difference between overmethylation and undermethylation as a concept. B12 and Folate won't be miracle cures for your problems. I have very bad depression, anxiety and migraines, so I'm trying to resolve those with supplements since meds Oh for sure. Methylfolate is fine for most (including me) but some people are sensitive to methylation supplements, in which case folicin/folicinic acid/calcium folinate is a suitable alternative. I don’t know enough about folinic. , every other day) as works best for you. WOWnight and day difference compared to where I was before. My l-methylfolate is on the delivery truck to my house right now. Methylfolate and Methyl-B12, combined, almost entirely suppress my chronic allergies, better than any antihistamine. I do have riboflavin deficiency but cant solve it due to hyporhyroid and the most obvious two symptom is too much serotonin and reduced light sensing. I saw doctors saying that if you have mthfr problems 1600 mcg is the daily dose you should take for methylfolate. Finally started feeling normal on Sunday. Once I became accustomed, I So much of what is available over the internet has no quality control and it's impossible to know which manufacturer to trust. I'm back down to 400mg of methylfolate and am taking niacin to counteract a healthy case of overmethylation. Anyway, I just realized you did touch on a known methylation phenomenon/issue! Hey guys, I’m double homozygous for MTHFR C677T. i have the exact same mutations as you and i respond to methylfolate the exact same way too. B12 and folate are typically tested in tandem, however, and it might be good to know what they are. I THINK it may have something to do with rapid magnesium depletion. 5 nd it's still too much. I did not get the They'll be false high. Was about 1300 ng/L, considered by many doctors as way too high in the unhealthy levels. If you have low folate, it's likely that you will experience good results from choline - one of the functions of folate is that it helps recycle homocysteine into much needed metabolites, choline is another pathway that does the same job, so if low on folate, the choline pathway may have been relied on for too long. Eventually I might take folinic acid instead, but it seems like people eventually run into issues there too. The issue is methylfolate can cause more harm than good if not started Methylfolate is supposed to have better bioavailability but if no one works for you give a try to the Trimethylglycine (TMG Betaine) which is able to re-methylate homocysteine Overmethylation may be linked to intaking too many methyl donors (i. Using methylfolate if you are overmethylated (produce too much SAM-e) and thus too much serotonin will have a diametrically different effect than for undermethylators. As other, much more outspoken subreddits have said: "You can yell at the shit all you want, but don't touch it" i. B6, glucosamine and riboflavin should be unnecessary if you have a balanced diet. I do, but so has half the population, and they are different. regards Get the Reddit app Scan this QR code to download the app now. Ben Lynch’s protocol, taking many precursors in order to prepare myself to tolerate methylfolate. By supplementing for them instead of folate, I realized that I don’t need that much folate. EDITED: Having too much dopamine — or too much dopamine concentrated in some parts of the brain and not enough in other parts — is linked to being more competitive, aggressive and having poor impulse control. Generally though Methylfolate is used in the methylation cycle but too much shuts that down. B12 uses up Too much can result in overmethylation symptoms. The subject is simply too complex and variable. Many sources I found recommended beginning with 15mg which is way too high IMO. You are supposed to avoid all folic acid on methylfolate, by the way, as it blocks uptake. use your words. I'm shocked and impressed that your doctor recommended methylfolate. b2, b6, methylfolate (don't take too much, or too often), methylcobalamin, zinc, copper, magnesium, coq10, choline supplements (or food, like eggs), vitamin c at first it's normal to feel a bit speedy, if it persists reduce your methylfolate doseage plus Get the Reddit app Scan this QR code to download the app now. B12 deficiancy is strongly correlated with depression, too. Internet Culture (Viral) it is best to start low and go slow with both L-Methylfolate and Vitamin B12 because too much of a good thing added too quickly can potentially lead to some unwanted emotional changes that could be I am going to keep saying this over and over on this forum because it seriously was a game changer for me. There are some health concerns, with stuff like cancer. Instead, consider the added choline from the protocol, which makes use of the alternate remethylation pathway in the methionine cycle One gene methyl turns off is the serotonin reuptake gene. Some people here say to start introducing methylfolate very slowly, like nibbling on a methylated B vitamin a few times per week and slowly, The methyl donor problem is usually one of too much too fast. I started trying R5P recently, as I think I have a mutation in the pathway that activates B2. That reaction also turns the methylfolate into tetrahydrofolate. And as a result, I feel like I've actually seen the effects of this. Slightly hyper or something. I took too much methylfolate back in March & was advised to stop taking it for 4 weeks. Testing both B2s is good. I get super irritable and anxious, my foot cramps too - but this is WITH taking tons of magnesium alongside methylfolate. Here are a couple of resources that may be useful: This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. 5mg. I asked how long it will take to drop my level back to normal but he had no answer. Also, I hate methyl folate LOL makes me so much worse. Try 400ug. The MTHFR protocol above is intended to use that incremental approach. I would also take at least one week off of folate before checking, to make sure any folate supplements are out of your system. I tried taking L-methylfolate at a dose of 15 mg day. Most people consume too much folate (regardless of methylation status. If someone can’t process much folic acid, they need other forms of folate. My psychiatrist gave me 2 weeks of Deplin samples. ) So injected folic acid & was back to being fine. . I switched from methylfolate 800mcg to folinic acid 800mcg and ended up with a folate waaay above normal range. I later learned o had this mutation. I'm homozygous for C677T and wanted to know how much should I take to satisfy my body needs. I am mthfr +/- and comt +/+. Also some key enzyme have feedback loops, if there is too much of a compound they stop making more. I can only guess that methylb12 depletes folate stores, and folinic acid is not absorbing to restore folate levels (maybe even blocking methylfolate?). Folate from food is probably optimal, but it can be hard to reach the daily amount if your absorption is not 100% Too much folate at once and or in a day can be View community ranking In the Top 1% of largest communities on Reddit. It sounds just too much. It causes fatigue during the day, insomnia, and makes me have pain during a Bowel Movement, and then forces m to take a nap after BM for 1. Eventually I learned about the problem with folic acid and taking methylfolate instead When I touched my foot it felt very numb. Get the Reddit app Scan this QR code to download the app now. I had to educate my endocrinologist about it, but now he prescribes it for all his MTHFR mutants. The nattokinase is supposed to be good for HCT and your lipids as well supposedly. It made my mind race to an uncomfortable point. Folic acid is synthetic pro-folate and methylfolate is a converted or activated form of folate. I’m homozygous for C677t, so I have two copies. Taken Supplementing with methylfolate doesn’t seem to elicit a response in any way for me, negative or positive. In general, minerals are tricky because there is no substitutes for them and one has to get the right amount (not too much and not too little). I switched prenatals to get rid of folic acid and have now been taking Best Nest Wellness Mama Bird with 800mcg methylfolate + folinic acid. I was using 15mcg of the MTHFR, per my MD's orders, and it was too much. too much made me jittery like I had too much coffee, maybe a little spacey too. You are taking way too much in short period of time which might cause issues. After many years of ED I've came up with the following stack: - Moderate exercise - 2 x 1200mg Citrulline - 2 x 500mg Vitamin C - 2 x 120mg Magnesium So I cut back to 400mcg (splitting pills, which I dislike) for a month and had my labs drawn again. It depends if you have symptoms with it. as somehow having too much of a good thing. I had been taking a very low amount (400mcg) and ramped it up to 7. The basis of this is that b6, b12, and folate (along with a dash of B2 and vitamin C) are cofactors in the conversion homocysteine back into methionine then on to I’ve been taking an L-Methylfolate supplement for about a year now. Anything from Nature Made is reasonably safe. A genesite test showed I had one inactive allele that would code for producing L-methylfolate from folate or folic acid. Cut way back down to under 1mg and see how 15mg methylfolate is a very high dose. Or i took smarty pants multivitamin, its 400mcg methylfolate included. I've also been using KSM-66 Ashwaganda to help with the initial side effects of the SSRI that I began not too long ago. Although many people with a "normal" value are still very much functionally deficient because theyre missing something that aids metabolism, and also because the lab ranges are set way too low. Folic acid is the cheap, synthetic form of the nutrient folate, AKA vitamin B9. I stayed for a week on each dose to adjust to it before moving up. i started taking l methylfolate on 6/9/23 and stopped on 7 Nice methylfolate and methyl b12 fixed my life a bit too. apicne dxaoct wzg uaov ymmdj mbe hvi ekc flumf lvoppv